Marine n-3 Polyunsaturated Fatty Acids and Cellular Senescence Markers in Incident Kidney Transplant Recipients: The Omega-3 Fatty Acids in Renal Transplantation (ORENTRA) Randomized Clinical Trial.

ABSTRACT:

Rationale & objective

Deterioration of kidney graft function is associated with accelerated cellular senescence. Marine n-3 polyunsaturated fatty acids (PUFAs) have favorable properties that may counteract cellular senescence development and damage caused by the senescence-associated secretory phenotype (SASP) secretome. Our objective was to investigate the potential effects of marine n-3 PUFA supplementation on the SASP secretome in kidney transplant recipients.

Study design

Exploratory substudy of the Omega-3 Fatty Acids in Renal Transplantation trial.

Setting & participants

Adult kidney transplant recipients with a functional kidney graft (defined as having an estimated glomerular filtration rate of >30 mL/min/1.73 m²) 8 weeks after engraftment were incl

SUBMITTER: Chan J 

PROVIDER: S-EPMC8664741 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature