Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Glomerular deposition of C4d is a widely used biomarker for activation of the lectin pathway in the complement system and is reported to be associated with kidney progression in immunoglobulin A nephropathy (IgAN). The aim of this study was to evaluate whether glomerular C4d deposition, as a new biomarker, improves the prediction of kidney prognosis in IgAN.

Study design

Systematic review and meta-analysis.

Setting & population

Patients with biopsy-proven primary IgAN without age limitations.Selection Criteria for Studies: Cross-sectional or cohort studies reporting the prevalence of glomerular C4d deposition or evaluating its association with IgAN progression.

Predictor

Glomerular C4d deposition.

Outcome

Composite progression event of a >30%

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8664744 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature