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Potential Role of 3-Dimensional Printed Vascular Models in Maintenance Hemodialysis Care.

ABSTRACT: Infiltration of a surgically placed hemodialysis vascular access is recognized as a major contributor to the high health care costs associated with dialysis-dependent patients. Three-dimensional (3D) modeling is a critical tool for proceduralists in preparation for surgical interventions. No such modeling is currently available for dialysis specialists to avoid the common complication of vascular access infiltration. Ferumoxytol-enhanced magnetic resonance angiography was used to generate 3D image data that could render a 3D resin-based model of a vascular access without exposing the patient to iodinated or gadolinium-based radiologic contrast. The technique required an abbreviated magnetic resonance angiography procedure interfaced with a 3D printer workstation. An interventional radiology suite was not required. In the described case, the brachial artery was clearly delineated from a cephalic vein to basilic vein bypass with a 3D spatial resolution of 1 mm. In conclusion, we demonstrate that this new technology pathway can provide preprocedural guidance that has the potential to significantly reduce the morbidity and cost associated with vascular access infiltration.

SUBMITTER: Li Y

PROVIDER: S-EPMC8664745 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature

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Potential Role of 3-Dimensional Printed Vascular Models in Maintenance Hemodialysis Care.

Li Yi Y Memon Aliza Anwar AA Aghayev Ayaz A Kabilan Kanmani K Luu Tuan T Hsiao Li-Li LL Zheng Sijie S Chin Matthew S MS Ghargouzloo Codi C Siedlecki Andrew A

Kidney medicine 20210924 6

Infiltration of a surgically placed hemodialysis vascular access is recognized as a major contributor to the high health care costs associated with dialysis-dependent patients. Three-dimensional (3D) modeling is a critical tool for proceduralists in preparation for surgical interventions. No such modeling is currently available for dialysis specialists to avoid the common complication of vascular access infiltration. Ferumoxytol-enhanced magnetic resonance angiography was used to generate 3D ima ...[more]

PMID: 34939020

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Project description:Assessing skin irritation potential is critical for the safety evaluation of topical drugs and other consumer products such as cosmetics. The use of advanced cellular models, as an alternative to replace animal testing in the safety evaluation for both consumer products and ingredients, is already mandated by law in the European Union (EU) and other countries. However, there has not yet been a large-scale comparison of the effects of topical-use compounds in different cellular skin models. This study assesses the irritation potential of topical-use compounds in different cellular models of the skin that are compatible with high throughput screening (HTS) platforms. A set of 451 topical-use compounds were first tested for cytotoxic effects using two-dimensional (2D) monolayer models of primary neonatal keratinocytes and immortalized human keratinocytes. Forty-six toxic compounds identified from the initial screen with the monolayer culture systems were further tested for skin irritation potential on reconstructed human epidermis (RhE) and full thickness skin (FTS) three-dimensional (3D) tissue model constructs. Skin irritation potential of the compounds was assessed by measuring tissue viability, trans-epithelial electrical resistance (TEER), and secretion of cytokines interleukin 1 alpha (IL-1α) and interleukin 18 (IL-18). Among known irritants, high concentrations of methyl violet and methylrosaniline decreased viability, lowered TEER, and increased IL-1α secretion in both RhE and FTS models, consistent with irritant properties. However, at low concentrations, these two compounds increased IL-18 secretion without affecting levels of secreted IL-1α, and did not reduce tissue viability and TEER, in either RhE or FTS models. This result suggests that at low concentrations, methyl violet and methylrosaniline have an allergic potential without causing irritation. Using both HTS-compatible 2D cellular and 3D tissue skin models, together with irritation relevant activity endpoints, we obtained data to help assess the irritation effects of topical-use compounds and identify potential dermal hazards.

Dataset Information

Potential Role of 3-Dimensional Printed Vascular Models in Maintenance Hemodialysis Care.

Publications

Potential Role of 3-Dimensional Printed Vascular Models in Maintenance Hemodialysis Care.

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