Trends in Adaptive Design Methods in Dialysis Clinical Trials: A Systematic Review.

ABSTRACT:

Rationale & objective

Adaptive design methods are intended to improve the efficiency of clinical trials and are relevant to evaluating interventions in dialysis populations. We sought to determine the use of adaptive designs in dialysis clinical trials and quantify trends in their use over time.

Study design

We completed a novel full-text systematic review that used a machine learning classifier (RobotSearch) for filtering randomized controlled trials and adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines.

Setting & study populations

We searched MEDLINE (PubMed) and ClinicalTrials.gov using sensitive dialysis search terms.

Selection criteria for studies

We included all randomized clinical trials with patients re

SUBMITTER: Judge C 

PROVIDER: S-EPMC8664746 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature