Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis.

ABSTRACT: Genetics (i.e., mutations) has been assumed to be the major factor in rheumatoid arthritis (RA) etiology, but accounts for a minority of the variance in disease risk for RA. In contrast to genetics, the environment can have dramatic impacts on epigenetics that associate with disease etiology. The current study used buccal cells and purified blood monocytes from two different clinical cohorts involving Caucasian or African American female populations with or without arthritis. The differential DNA methylation regions (DMRs) between the control and RA populations were identified with an epigenome-wide association study. The DMRs (i.e., epimutations) identified in the buccal cells and monocytes were found to be distinct. The DMR associated genes were identified and many have previously been s

SUBMITTER: Craig G 

PROVIDER: S-EPMC8664902 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature