Ontology highlight
ABSTRACT:
SUBMITTER: Arciero E
PROVIDER: S-EPMC8664933 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Arciero Elena E Dogra Sufyan A SA Malawsky Daniel S DS Mezzavilla Massimo M Tsismentzoglou Theofanis T Huang Qin Qin QQ Hunt Karen A KA Mason Dan D Sharif Saghira Malik SM van Heel David A DA Sheridan Eamonn E Wright John J Small Neil N Carmi Shai S Iles Mark M MM Martin Hilary C HC
Nature communications 20211210 1
Previous genetic and public health research in the Pakistani population has focused on the role of consanguinity in increasing recessive disease risk, but little is known about its recent population history or the effects of endogamy. Here, we investigate fine-scale population structure, history and consanguinity patterns using genotype chip data from 2,200 British Pakistanis. We reveal strong recent population structure driven by the biraderi social stratification system. We find that all subgr ...[more]