Legacy effect on neuropsychological function in HIV-infected men on combination antiretroviral therapy.

ABSTRACT:

Objective

To determine whether combination antiretroviral therapy (cART) initiation alters the trajectory of cognitive performance in HIV+ men, and whether cognition prior to cART predicts postcART function.

Design

Longitudinal cohort study. Multicenter AIDS Cohort Study.

Methods

From an initial set of 3701 men with complete neuropsychological data, men with HIV infection were initially matched with men without infection on cognitive status, race, age, and timeline (T0 defined as cART initiation). Propensity score matching was then used to match pairs on depressive symptoms at T0, education, T0 cognitive scores, and recruitment cohort. There were 506 matched pairs of infected and uninfected men in the final analysis. Mixed effect models were constructed to analyze the

SUBMITTER: Qu Y 

PROVIDER: S-EPMC8665003 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature