Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity.

ABSTRACT: Neural activity sculpts circuit wiring in many animals. In vertebrates, patterned spontaneous network activity (PaSNA) generates sensory maps and establishes local circuits.^1-3 However, it remains unclear how PaSNA might shape neuronal circuits and behavior in invertebrates. Previous work in the developing Drosophila embryo discovered intrinsic muscle activity that did not require synaptic transmission, and hence was myogenic, preceding PaSNA.^4-6 These studies, however, monitored muscle movement, not neural activity, and were therefore unable to observe how myogenic activity might relate to subsequent neural network engagement. Here we use calcium imaging to directly record neural activity and characterize the emergence of PaSNA. We demonstrate that the spatiotemporal

SUBMITTER: Carreira-Rosario A 

PROVIDER: S-EPMC8665011 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature