Evaluating whole-genome expression differences in idiopathic and diabetic adhesive capsulitis.

ABSTRACT:

Background

Diabetic patients have a greater incidence of adhesive capsulitis (AC) and a more protracted disease course than patients with idiopathic AC. The purpose of this study was to compare gene expression differences between AC with diabetes mellitus and AC without diabetes mellitus.

Methods

Shoulder capsule samples were prospectively obtained from diabetic or nondiabetic patients who presented with shoulder dysfunction and underwent arthroscopy (N = 16). Shoulder samples of AC with and without diabetes (n = 8) were compared with normal shoulder samples with and without diabetes as the control group (n = 8). Shoulder capsule samples were subjected to whole-transcriptome RNA sequencing, and differential expression was analyzed with EdgeR. Only genes with a false discover

SUBMITTER: Gordon JA 

PROVIDER: S-EPMC8665043 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature