The BORDER family of negative transcription elongation factors regulates flowering time in Arabidopsis.

ABSTRACT: Transcription initiation has long been considered a primary regulatory step in gene expression. Recent work, however, shows that downstream events, such as transcription elongation, can also play important roles.^1-3 A well-characterized example from animals is promoter-proximal pausing, where transcriptionally engaged Pol II accumulates 30-50 bp downstream of the transcription start site (TSS) and is thought to enable rapid gene activation.² Plants do not make widespread use of promoter-proximal pausing; however, in a phenomenon known as 3' pausing, a significant increase in Pol II is observed near the transcript end site (TES) of many genes.^4-6 Previous work has shown that 3' pausing is promoted by the BORDER (BDR) family of negative transcription elongati

SUBMITTER: Yu X 

PROVIDER: S-EPMC8665048 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature