A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle.

ABSTRACT: Virus infection necessarily requires redirecting cellular resources toward viral progeny production. Adenovirus encodes the histone-like protein VII, which causes catastrophic global reorganization of host chromatin to promote virus infection. Protein VII recruits the family of high mobility group box (HMGB) proteins to chromatin along with the histone chaperone SET. As a consequence of this recruitment, we find that protein VII causes chromatin depletion of several linker histone H1 isoforms. The relationship between linker histone H1 and the functionally opposite HMGB proteins is critical for higher-order chromatin structure. However, the physiological consequences of perturbing this relationship are largely unknown. Here, we employ complementary systems in Saccharomyces cerevisiae and h

SUBMITTER: Lynch KL 

PROVIDER: S-EPMC8665055 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature