Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.

ABSTRACT: Pulses of the steroid hormone ecdysone act through transcriptional cascades to direct the major developmental transitions during the Drosophila life cycle. These include the prepupal ecdysone pulse, which occurs 10 ​hours after pupariation and triggers the onset of adult morphogenesis and larval tissue destruction. E93 encodes a transcription factor that is specifically induced by the prepupal pulse of ecdysone, supporting a model proposed by earlier work that it specifies the onset of adult development. Although a number of studies have addressed these functions for E93, little is known about its roles in the salivary gland where the E93 locus was originally identified. Here we show that E93 is required for development through late pupal stages, with mutants displaying defects in adult di

SUBMITTER: Lam G 

PROVIDER: S-EPMC8665130 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature