The association of parity and breastfeeding with anti-Mullerian hormone levels at two time points.

ABSTRACT:

Objective

To evaluate the association between parity and breastfeeding and anti-Müllerian hormone levels (AMH) and change in AMH levels over time. Furthermore, we examined whether AMH levels mediate the relation of parity and breastfeeding with age at menopause.

Study design

Observational, prospective cohort study.

Main outcome measures

AMH levels were assessed in a subset of premenopausal participants in the Nurses' Health Study II, including 1619 women who provided a blood sample in 1996-1999 and an additional 800 women who provided a second premenopausal sample in 2010-2012.

Results

In multivariable linear regression models adjusted for parity, body mass index, smoking, and other factors, mean log AMH levels in 1996-1999 were 39% higher in women reporting ≥2

SUBMITTER: Grimes NP 

PROVIDER: S-EPMC8665225 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature