Dysbiosis and relapse-related microbiome in inflammatory bowel disease: A shotgun metagenomic approach.

ABSTRACT: Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), affect several million people worldwide. CD and UC are characterized by periods of clinical remission and relapse. Although IBD patients present chronic alterations of the gut microbiome, called dysbiosis, little attention has been devoted to the relapse-related microbiome. To address this gap, we generated shotgun metagenomic data from the stools of two European cohorts-134 Spanish (followed up for one year) and 49 Belgian (followed up for 6 months) subjects-to characterize the microbial taxonomic and metabolic profiles present. To assess the predictive value of microbiome data, we added the taxonomic profiles generated from a previous study of 130 Americans. Our results revealed that

SUBMITTER: Serrano-Gomez G 

PROVIDER: S-EPMC8665270 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature