Biological factors in the synthetic construction of overlapping genes.

ABSTRACT: Overlapping genes (OLGs) with long protein-coding overlapping sequences are disallowed by standard genome annotation programs, outside of viruses. Recently however they have been discovered in Archaea, diverse Bacteria, and Mammals. The biological factors underlying life's ability to create overlapping genes require more study, and may have important applications in understanding evolution and in biotechnology. A previous study claimed that protein domains from viruses were much better suited to forming overlaps than those from other cellular organisms - in this study we assessed this claim, in order to discover what might underlie taxonomic differences in the creation of gene overlaps. After overlapping arbitrary Pfam domain pairs and evaluating them with Hidden Markov Models we find OLG

SUBMITTER: Wichmann S 

PROVIDER: S-EPMC8665328 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature