Association of Plasma Tau With Mortality and Long-term Neurocognitive Impairment in Survivors of Pediatric Cerebral Malaria and Severe Malarial Anemia.

ABSTRACT:

Importance

Cerebral malaria (CM) and severe malarial anemia (SMA) are associated with persistent neurocognitive impairment (NCI) among children in Africa. Identifying blood biomarkers of acute brain injury that are associated with future NCI could allow early interventions to prevent or reduce NCI in survivors of severe malaria.

Objective

To investigate whether acutely elevated tau levels are associated with future NCI in children after CM or SMA.

Design, setting, and participants

This prospective cohort study was conducted at Mulago National Referral Hospital in Kampala, Uganda, from March 2008 to October 2015. Children aged 1.5 to 12 years with CM (n = 182) or SMA (n = 162) as well as community children (CC; n = 123) were enrolled in the study. Data analysis was con

SUBMITTER: Datta D 

PROVIDER: S-EPMC8665370 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature