Adjuvant therapy may be omitted for oral cavity cancer with only one positive lymph node.

ABSTRACT:

Objective

Whether to administer adjuvant treatment is a matter of great debate for oral cavity cancer harboring a single positive node without extranodal extension and positive margin (defined as low/intermediate risk pN1_new in this study).

Methods

A total of 243 low/intermediate risk pN1_new patients with oral cavity cancer who received curative surgery were included. Overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS) were compared between patients receiving adjuvant treatment and observation alone.

Results

For patients receiving adjuvant therapy vs observation, the differences in outcomes were not statistically significant in terms of 5-year OS, LRFS

SUBMITTER: Chen WY 

PROVIDER: S-EPMC8665423 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature