Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy.

ABSTRACT: IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally. Increasing evidence suggests the importance of host immunity in the development of IgAN, but its dynamics during the early stage of IgAN are still largely unclear. Here we successfully resolved the early transcriptomic changes in immune cells of IgAN by conducting single-cell RNA-sequencing (scRNA-seq) with peripheral blood mononuclear cells. The differentially expressed genes (DEGs) between control and IgAN were predominantly enriched in NK cell-mediated cytotoxicity and cell killing pathways. Interestingly, we discovered that the number and cytotoxicity of NK cells are significantly reduced in IgAN patients, where both the number and marker genes of NK cells were negatively associated with the clinical paramet

SUBMITTER: Zeng H 

PROVIDER: S-EPMC8665497 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature