Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity.

ABSTRACT:

Background

Obesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut microbiome. Here, we evaluated gut microbiome features and their associations with immigration, dietary intake, and obesity in 2640 individuals from a population-based study of US Hispanics/Latinos.

Results

The fecal shotgun metagenomics data indicate that greater US exposure is associated with reduced ɑ-diversity, reduced functions of fiber degradation, and alterations in individual taxa, potentially related to a westernized diet. However, a majority of gut bacterial genera show paradoxical associations, being reduced with US exposure and increased with fiber intake, but increased with obesity. The observed

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8665519 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature