Nanoscale characterization of drug-induced microtubule filament dysfunction using super-resolution microscopy.

ABSTRACT:

Background

The integrity of microtubule filament networks is essential for the roles in diverse cellular functions, and disruption of its structure or dynamics has been explored as a therapeutic approach to tackle diseases such as cancer. Microtubule-interacting drugs, sometimes referred to as antimitotics, are used in cancer therapy to target and disrupt microtubules. However, due to associated side effects on healthy cells, there is a need to develop safer drug regimens that still retain clinical efficacy. Currently, many questions remain open regarding the extent of effects on cellular physiology of microtubule-interacting drugs at clinically relevant and low doses. Here, we use super-resolution microscopies (single-molecule localization and optical fluctuation based) to reveal

SUBMITTER: Rozario AM 

PROVIDER: S-EPMC8665533 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature