Drug targeting of aminoacyl-tRNA synthetases in Anopheles species and Aedes aegypti that cause malaria and dengue.

ABSTRACT:

Background

Mosquito-borne diseases have a devastating impact on human civilization. A few species of Anopheles mosquitoes are responsible for malaria transmission, and while there has been a reduction in malaria-related deaths worldwide, growing insecticide resistance is a cause for concern. Aedes mosquitoes are known vectors of viral infections, including dengue, yellow fever, chikungunya, and Zika. Aminoacyl-tRNA synthetases (aaRSs) are key players in protein synthesis and are potent anti-infective drug targets. The structure-function activity relationship of aaRSs in mosquitoes (in particular, Anopheles and Aedes spp.) remains unexplored.

Methods

We employed computational techniques to identify aaRSs from five different mosquito species (Anopheles culicifacies, Anopheles

SUBMITTER: Chakraborti S 

PROVIDER: S-EPMC8665550 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature