Genome-wide characterization, evolution, structure, and expression analysis of the F-box genes in Caenorhabditis.

ABSTRACT:

Background

F-box proteins represent a diverse class of adaptor proteins of the ubiquitin-proteasome system (UPS) that play critical roles in the cell cycle, signal transduction, and immune response by removing or modifying cellular regulators. Among closely related organisms of the Caenorhabditis genus, remarkable divergence in F-box gene copy numbers was caused by sizeable species-specific expansion and contraction. Although F-box gene number expansion plays a vital role in shaping genomic diversity, little is known about molecular evolutionary mechanisms responsible for substantial differences in gene number of F-box genes and their functional diversification in Caenorhabditis. Here, we performed a comprehensive evolution and underlying mechanism analysis of F-box genes in five s

SUBMITTER: Wang A 

PROVIDER: S-EPMC8665587 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature