Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.

ABSTRACT:

Introduction/background & aims

Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life. Cytokines and chemokines contribute to this dynamic immune signaling network and can be altered by many factors, such as infection. Newborns undergo dynamic changes important to health and disease, yet there is limited information regarding human neonatal plasma cytokine and chemokine concentrations over the first week of life. The few available studies are limited by small sample size, cross-sectional study design, or focus on perturbed host states like severe infection or prematurit

SUBMITTER: Smolen KK 

PROVIDER: S-EPMC8665647 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature