Apolipoprotein E Gene Polymorphism and Coronary Artery Disease Risk Among Patients in Northwest China.

ABSTRACT:

Purpose

The association between apolipoprotein E (ApoE) gene polymorphisms and the risk of coronary artery disease (CAD) among different populations has been assessed in numerous previous studies, but the results remain inconclusive. The present study aimed to determine the role of ApoE genotypes in CAD risk and the interrelationships between lipid profiles and ApoE alleles and genotypes among the population of northwest China.

Patients and methods

This study was performed on 308 patients with CAD and 308 control participants. ApoE gene polymorphism was analysed using the polymerase chain reaction and hybridization.

Results

The findings indicated that the frequencies of ε3/ε4 genotype and ε4 allele frequency were significantly higher in patients with CAD than in the c

SUBMITTER: Ma W 

PROVIDER: S-EPMC8665779 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature