Neuroimaging Biomarkers of New-Onset Psychiatric Disorders Following Traumatic Brain Injury.

ABSTRACT: Traumatic brain injury (TBI) has traditionally been associated with cognitive and behavioral changes during both the acute and chronic phases of injury. Because of its noninvasive nature, neuroimaging has the potential to provide unique information on underlying macroscopic and microscopic biological mechanisms that may serve as causative agents for these neuropsychiatric sequelae. This broad scoping review identifies at least 4 common macroscopic pathways that exist between TBI and new-onset psychiatric disorders, as well as several examples of how neuroimaging is currently being utilized in clinical research. The review then critically examines the strengths and limitations of neuroimaging for elucidating TBI-related microscopic pathology, such as microstructural changes, neuroinflammati

SUBMITTER: Mayer AR 

PROVIDER: S-EPMC8665933 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature