CMR Characteristics, gene variants and long-term outcome in patients with left ventricular non-compaction cardiomyopathy.

ABSTRACT:

Background

As the paucity of data focusing on evaluating cardiac structure and function in patients with or without gene mutation, this study was sought to investigate the correlation between genotype and cardiac magnetic resonance (CMR) phenotype in patients with left ventricular non-compaction cardiomyopathy (LVNC) and to explore prognostic relevance in this cohort if possible.

Methods

Patients with LVNC who underwent CMR and targeted gene sequencing between 2006 and 2016 were retrospectively evaluated. Demographic data, clinical presentation, genetic analysis, CMR data and follow-up data of all participants were collected.

Results

Compared to negative genotype (G-) group, patients with positive genotype (G+) had larger left atrial volume (LAV), and carriers of mult

SUBMITTER: Zhou D 

PROVIDER: S-EPMC8665949 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature