Enhanced synchronization between prelimbic and infralimbic cortices during fear extinction learning.

ABSTRACT: The ability to extinguish aversive memories when they are no longer associated with danger is critical for balancing survival with competing adaptive demands. Previous studies demonstrated that the infralimbic cortex (IL) is essential for extinction of learned fear, while neural activity in the prelimbic cortex (PL) facilitates fear responding and is negatively correlated with the strength of extinction memories. Though these adjacent regions in the prefrontal cortex maintain mutual synaptic connectivity, it has been unclear whether PL and IL interact functionally with each other during fear extinction learning. Here we addressed this question by recording local field potentials (LFPs) simultaneously from PL and IL of awake behaving rats during extinction of auditory fear memories. We foun

SUBMITTER: Watanabe M 

PROVIDER: S-EPMC8666018 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature