A new experimental design to study inflammation-related versus non-inflammation-related depression in mice.

ABSTRACT:

Background

Major depressive disorder (MDD) represents a major public health concern, particularly due to its steadily rising prevalence and the poor responsiveness to standard antidepressants notably in patients afflicted with chronic inflammatory conditions, such as obesity. This highlights the need to improve current therapeutic strategies, including by targeting inflammation based on its role in the pathophysiology and treatment responsiveness of MDD. Nevertheless, dissecting the relative contribution of inflammation in the development and treatment of MDD remains a major issue, further complicated by the lack of preclinical depression models suitable to experimentally dissociate inflammation-related vs. inflammation-unrelated depression.

Methods

While current models usua

SUBMITTER: Cardinal P 

PROVIDER: S-EPMC8666053 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature