Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia.

ABSTRACT:

Background

Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory responses, mitochondrial proteins, extracellular remodeling and estrogen-mediated cardioprotective signaling pathways related to post-ischemic recovery, which were associated with better cardiac functional outcomes in females. We aimed to investigate the early, sex-specific functional and proteomic changes following myocardial ischemia in an unbiased approach.

Methods

Ischemia was induced in male (M-Isch) and female (F-Isch) rats with sc. injection of isoproterenol (85 mg/kg) daily for 2 days, while controls (M-Co, F-Co) received sc. saline solution. At 48 h af

SUBMITTER: Barta BA 

PROVIDER: S-EPMC8666068 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature