Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.

ABSTRACT: Convergent advances in the field of soft matter, macromolecular chemistry, and engineering have led to the development of biomaterials that possess autonomous, adaptive, and self-healing characteristics similar to living systems. These rationally designed biomaterials can surpass the capabilities of their parent material. Herein, the modification of hyaluronic acid (HA) to exhibit self-healing properties is described, and its physical and biological function both in vitro and in vivo is studied. The in vitro findings showed that self-healing HA designed to undergo self-repair improves lubrication, enhances free radical scavenging, and attenuates enzymatic degradation compared to unmodified HA. Longitudinal imaging following intraarticular injection of self-healing HA shows improved in vivo

SUBMITTER: Gilpin A 

PROVIDER: S-EPMC8666142 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature