Monitoring one-carbon metabolism by mass spectrometry to assess liver function and disease.

ABSTRACT: Precision medicine promises to overcome the constraints of the traditional "one-for-all" healthcare approach through a clear understanding of the molecular features of a disease, allowing for innovative and tailored treatments. State-of-the-art proteomics has the potential to accurately explore the human proteome to identify, quantify, and characterize proteins associated with disease progression. There is a pressing need for informative biomarkers to diagnose liver disease early in its course to prevent severe disease for which no efficient treatment is yet available. Here, we propose the concept of a cellular pathway as a functional biomarker, whose monitorization may inform normal and pathological status. We have developed a standardized targeted selected-reaction monitoring assay to de

SUBMITTER: Guerrero L 

PROVIDER: S-EPMC8666175 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature