A hybrid systems biology and systems pharmacology investigation of Zingerone's effects on reconstructed human epidermal tissues.

ABSTRACT:

Background

As individuals live longer, elderly populations can be expected to face issues. This pattern urges researchers to investigate the aging concept further to produce successful anti-aging agents. In the current study, the effects of Zingerone (a natural compound) on epidermal tissues were analyzed using a bioinformatics approach.

Methods

For this purpose, we chose the GEO dataset GSE133338 to carry out the systems biology and systems pharmacology approaches, ranging from identifying the differentially expressed genes to analyzing the gene ontology, determining similar structures of Zingerone and their features (i.e., anti-oxidant, anti-inflammatory, and skin disorders), constructing the gene-chemicals network, analyzing gene-disease relationships, and validating sign

SUBMITTER: Amjad E 

PROVIDER: S-EPMC8666180 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature