Putative antigenic proteins identified by comparative and subtractive reverse vaccinology in necrotic enteritis-causing Clostridium perfringens isolated from broiler chickens.

ABSTRACT: BACKGROUND:Avian necrotic enteritis (NE) caused by Clostridium perfringens is a disease with a major economic impact, generating losses estimated to 6 billion of dollars annually for the poultry industry worldwide. The incidence of the disease is particularly on the rise in broiler chicken flocks eliminating the preventive use of antibiotics. To date, no alternative allows for the efficient prevention of NE and a control of the disease using a vaccinal strategy would be mostly prized. For this purpose, comparative and subtractive reverse vaccinology identifying putative immunogenic bacterial surface proteins is one of the most promising approaches. RESULTS:A comparative genomic study was performed on 16 C. perfringens strains isolated from healthy broiler chickens and from broilers affecte

SUBMITTER: Meniai I 

PROVIDER: S-EPMC8666345 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature