Identification and Validation of an Immune-related Prognostic Signature for Hepatocellular Carcinoma.

ABSTRACT:

Background and aims

The immune system plays vital roles in hepatocellular carcinoma (HCC) initiation and progression. The present study aimed to construct an immune-gene related prognostic signature (IRPS) for predicting the prognosis of HCC patients.

Methods

Gene expression data were retrieved from The Cancer Genome Atlas database. The IRPS was established via least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis. The prognostic values of the IRPS were further validated using the International Cancer Genome Consortium (ICGC) dataset.

Results

A total of 62 genes were identified as candidate immune-related prognostic genes. According to the results of Lasso and multivariate Cox regression analysis, we established an IRPS and c

SUBMITTER: Xia X 

PROVIDER: S-EPMC8666365 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature