Novel variations in spermatogenic transcription regulators RFX2 and TAF7 increase risk of azoospermia.

ABSTRACT:

Purpose

Genetic etiology of idiopathic male infertility is enigmatic owing to involvement of multiple gene regulatory networks in spermatogenesis process. Any change in optimal function of the transcription factors involved in this process owing to polymorphisms/mutations may increase the risk of infertility. We investigated polymorphisms/mutations of spermatogenic transcription regulators TAF7 and RFX2 and analysed their association with incidence of azoospermia among the men from West Bengal, India.

Methods

Genotyping was carried by Sanger's dideoxy sequencing of 130 azoospermic men who were detected negative in Y chromosome microdeletion screening and 140 healthy controls. Association study was done by suitable statistical methods. In silico analysis was performed to infe

SUBMITTER: Pal S 

PROVIDER: S-EPMC8666464 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature