Different doses of enoxaparin in the prevention of postoperative abdominal adhesions. Experimental study.

ABSTRACT:

Background

Postoperative abdominal adhesions (PAAs) are present in more than 90% of patients undergoing abdominal surgery. They are a cause of chronic pain, hospitalizations, multiple surgeries, and infertility in women of reproductive age. The participation of three processes have been recognized: coagulation, fibrinolysis, and inflammation. The usefulness of subcutaneous enoxaparin in their prevention has been established. The objective is to establish the safest and most efficient dose for PAA prevention by testing five different doses of subcutaneous enoxaparin (0.25, 0.5, 1, 1.5, and 2 mg/kg/day) given in one dose/day for seven days.

Material and methods

Fifty Sprague-Dawley rats were studied, 10 in each group. Adhesions were induced through controlled rubbing of the ce

SUBMITTER: Guzman-Valdivia Gomez G 

PROVIDER: S-EPMC8666521 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature