Dataset Information

Different doses of enoxaparin in the prevention of postoperative abdominal adhesions. Experimental study.

ABSTRACT:

Background

Postoperative abdominal adhesions (PAAs) are present in more than 90% of patients undergoing abdominal surgery. They are a cause of chronic pain, hospitalizations, multiple surgeries, and infertility in women of reproductive age. The participation of three processes have been recognized: coagulation, fibrinolysis, and inflammation. The usefulness of subcutaneous enoxaparin in their prevention has been established. The objective is to establish the safest and most efficient dose for PAA prevention by testing five different doses of subcutaneous enoxaparin (0.25, 0.5, 1, 1.5, and 2 mg/kg/day) given in one dose/day for seven days.

Material and methods

Fifty Sprague-Dawley rats were studied, 10 in each group. Adhesions were induced through controlled rubbing of the cecum and suturing of an incision in the terminal ileum. Two independent observers recorded the degree of adhesion formation at 14 days and histologically studied the adhesions.

Statistical analysis

ANOVA compared group averages. The nonparametric Kruskal-Wallis test was used to identify group differences.

Results

The 0.5 mg/kg/day group had greater formation of adhesions (p < 0.001). There was no significant difference between the 1.5 and 2 mg/kg/day groups, though the latter group had an incidence of 27.2% of bleeding in the abdominal cavity. The degree of adhesions in the histological sections coincided with the macroscopic findings. The interobserver agreement was kappa = 0.88 (very good).

Conclusion

The safe and effective dose of subcutaneous enoxaparin to prevent PAA formation was 0.5-1.5 mg/kg/day for seven days.

SUBMITTER: Guzman-Valdivia Gomez G

PROVIDER: S-EPMC8666521 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

Different doses of enoxaparin in the prevention of postoperative abdominal adhesions. Experimental study.

Guzmán-Valdivia Gómez Gilberto G Tena-Betancourt Eduardo E Angulo Trejo Mónica M

Annals of medicine and surgery (2012) 20211203

<h4>Background</h4>Postoperative abdominal adhesions (PAAs) are present in more than 90% of patients undergoing abdominal surgery. They are a cause of chronic pain, hospitalizations, multiple surgeries, and infertility in women of reproductive age. The participation of three processes have been recognized: coagulation, fibrinolysis, and inflammation. The usefulness of subcutaneous enoxaparin in their prevention has been established. The objective is to establish the safest and most efficient dos ...[more]

PMID: 34917351

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Dataset Information

Different doses of enoxaparin in the prevention of postoperative abdominal adhesions. Experimental study.

Background

Material and methods

Statistical analysis

Results

Conclusion

Publications

Different doses of enoxaparin in the prevention of postoperative abdominal adhesions. Experimental study.

Similar Datasets

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