Vitamin D receptor gene polymorphisms and risk of breast cancer in Iranian women.

ABSTRACT:

Objectives

Vitamin D deficiency is a driving force of common cancers like breast cancer. Vitamin D receptor (VDR) can play a tumor suppressor role by helping the precise function of vitamin D in cells such as modulation TGF-β signaling pathway. This study aimed to investigate the association of VDR gene variants and susceptibility to breast cancer in Iranian women.

Methods

Genomic DNAs were isolated from blood samples of 161 women with breast cancer and 150 healthy women. After amplification of five positions of VDR gene, the prepared amplicons were digested with TaqI, ApaI, BsmI, Cdx2, and FokI restriction enzymes.

Results

Subsequently, the digested products were electrophoresed on the 1.5% agarose gel. Odds ratios (ORs) for breast cancer

SUBMITTER: Kazemi SM 

PROVIDER: S-EPMC8666522 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature