Myofilament Phosphorylation in Stem Cell Treated Diastolic Heart Failure.

ABSTRACT:

Rationale

Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, cardiac stiffness, Ca²⁺-sensitivity, and mechanosensing. Treatment with cardiosphere-derived cells (CDCs) restores normal diastolic function, attenuates fibrosis and inflammation, and improves survival in a rat HFpEF model.

Objective

Phosphorylation changes that underlie HFpEF and those reversed by CDC therapy, with a focus on the sarcomeric subproteome were analyzed.

Methods and results

Dahl salt-sensitive rats fed a high-salt diet, with echocardiographically verified diastolic dysfunction, were randomly assigned to either intracoronary CDCs or placebo

SUBMITTER: Soetkamp D 

PROVIDER: S-EPMC8666591 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature