Diffusion MRI fiber diameter for muscle denervation assessment.

ABSTRACT:

Background

To develop and evaluate a diffusion MRI-based apparent muscle fiber diameter (AFD) method in patients with muscle denervation. It was hypothesized that AFD differences between denervated, non-denervated and control muscles would be greater than those from standard diffusion metrics.

Methods

A spin-echo diffusion acquisition with multi-b-valued diffusion sampling was used. An orientation-invariant dictionary approach utilized a cylinder-based forward model and multi-compartment model for obtaining restricted and free fractions. Simulations were performed to determine precision, bias, and optimize dictionary parameters. In all, 18 exams of patients with muscle denervation and 8 exams of healthy subjects were performed at 3T. Six regions of interests (ROIs) within se

SUBMITTER: Tan ET 

PROVIDER: S-EPMC8666740 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature