Use of antibiotics and colorectal cancer risk: a primary care nested case-control study in Belgium.

ABSTRACT:

Objectives

To examine the association between the use of oral antibiotics and subsequent colorectal cancer risk.

Design

Matched case-control study.

Setting

General practice centres participating in the Integrated Computerised Network database in Flanders, Belgium.

Participants

In total, 1705 cases of colorectal cancer diagnosed between 01 January 2010 and 31 December 2015 were matched to 6749 controls by age, sex, comorbidity and general practice centre.

Primary outcome measure

The association between the number of prescriptions for oral antibiotics and the incidence of colorectal cancer over a period of 1-10 years, estimated by a conditional logistic regression model.

Results

A significantly increased risk of colorectal cancer (OR 1.25, 95% CI 1.

SUBMITTER: Van der Meer J 

PROVIDER: S-EPMC8666897 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature