CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles.

ABSTRACT: Extracellular vesicles (EVs) transfer functional molecules between cells. CD63 is a widely recognized EV marker that contributes to EV secretion from cells. However, the regulation of its expression remains largely unknown. Ferritin is a cellular iron storage protein that can also be secreted by the exosome pathway, and serum ferritin levels classically reflect body iron stores. Iron metabolism-associated proteins such as ferritin are intricately regulated by cellular iron levels via the iron responsive element-iron regulatory protein (IRE-IRP) system. Herein, we present a novel mechanism demonstrating that the expression of the EV-associated protein CD63 is under the regulation of the IRE-IRP system. We discovered a canonical IRE in the 5' untranslated region of CD63 messenger RNA that is

SUBMITTER: Yanatori I 

PROVIDER: S-EPMC8667049 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature