The role of autoantibody detection in the diagnosis and staging of lung cancer.

ABSTRACT:

Background

Previously, the clinical value of seven autoantibodies (p53, PGP9.5, SOX2, GAGE7, GBU4-5, MAGEA1, and CAGE) has been surveyed in our pilot observation and other published studies. Herein, we aimed to further investigate the role of these autoantibodies in the diagnosis and staging of LC.

Methods

We included a total of 135 individuals, who were divided into a Lung cancer (LC) group and a control group according to the final diagnosis. Seven autoantibody detection kits were used (ELISA method) for the expression measurement. The patients' demographics information (e.g., age, gender, and smoking history) were also documented.

Results

Among the seven types of autoantibodies, only P53 and GBU4-5 were significantly increased in the LC group compared to the contro

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8667094 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature