Characteristics of genomic mutations and signaling pathway alterations in thymic epithelial tumors.

ABSTRACT:

Background

To elucidate the mechanisms of thymic epithelial tumor (TET) canceration by characterizing genomic mutations and signaling pathway alterations.

Methods

Primary tumor and blood samples were collected from 21 patients diagnosed with TETs (thymoma and thymic cancer), 15 of whom were screened by nucleic acid extraction and whole exon sequencing. Bioinformatics was used to comprehensively analyze the sequencing data for these samples, including gene mutation information and the difference of tumor mutation burden (TMB) between thymoma and thymic carcinoma groups. We performed signaling pathway and functional enrichment analysis using the WebGestalt 2017 toolkit.

Results

ZNF429 (36%) was the gene with the highest mutation frequency in thymic carcinoma. Mut

SUBMITTER: Yang W 

PROVIDER: S-EPMC8667121 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature