GSK-3β activates NF-κB to aggravate caerulein-induced early acute pancreatitis in mice.

ABSTRACT:

Background

Acute pancreatitis is a life-threatening disease which causes considerable morbidity and mortality. However, no specific and effective treatments are currently available for this critical condition, which is mainly due to the insufficient understanding of the early cellular events in the initial phase of acute pancreatitis. Previous researchers have reported that two independent events, intra-acinar trypsinogen and NF-κB activation, are of equal importance in the early development of acute pancreatitis. GSK-3β, an essential molecule in multiple physiopathological processes including inflammation, is associated with the expression of the NF-κB pathway.

Methods

We investigated whether GSK-3β affected the expression of cytokines produced b

SUBMITTER: Fu X 

PROVIDER: S-EPMC8667130 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature