The role of TGF-β pathway alterations in immune regulation as a potential pan-cancer biomarker in immunotherapy.

ABSTRACT:

Background

Depending on the context, the transforming growth factor beta (TGF-β) signaling pathway is involved in opposing cell processes of tumor suppression and tumor promotion. However, the effects of TGF-β pathway on immunotherapy efficacy have not yet been systematically investigated.

Methods

In this study, we have extracted the available data of whole-exome sequencing, messenger RNA (mRNA) expression, baseline characterization, and prognosis information of 10,912 pan-cancer patients from The Cancer Genome Atlas to explore the role of TGF-β pathway in immune regulation. Formalin-fixed, paraffin-embedded tissue samples from 6,717 Chinese cancer patients assayed by next-generation sequencing (NGS) were used as a validation cohort (3DMed cohort). Data sets from the public

SUBMITTER: Liang Y 

PROVIDER: S-EPMC8667138 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature