Cancer Photothermal Therapy with ICG-Conjugated Gold Nanoclusters.

ABSTRACT: The coming era of precision nanomedicine demands engineered nanoparticles that can be readily translated into the clinic, like that of molecular agents, without being hindered by intrinsic size heterogeneity and long-term body retention. Herein we report that conjugation of indocyanine green (ICG), an FDA-approved near-infrared (NIR) dye, onto an atomically precise glutathione-coated Au25 (GS-Au25) nanocluster led to a molecular-like photothermal nanoparticle (ICG₄-GS-Au25) with significantly enhanced ICG photostability and tumor targeting. Under weak NIR light irradiation conditions, free ICG failed to suppress tumor growth but the original tumors were completely eradicated with ICG₄-GS-Au25. In the meantime, "off-target" ICG₄-GS-Au25 was effectively clear

SUBMITTER: Jiang X 

PROVIDER: S-EPMC8667163 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature