Progesterone Aggravates Lung Fibrosis in a Mouse Model of Systemic Sclerosis.

ABSTRACT:

Background

Gender-related factors have explained the higher prevalence of autoimmune diseases in women. Sex hormones play a key role in the immune system and parenchymal cells function; therefore, these hormones can be important in the pathogenesis of autoimmune diseases as a risk or beneficial factor. Lung fibrosis is the main cause of mortality in systemic sclerosis, a female predominant autoimmune disease. The objective of this study was to examine the effect of progesterone on lung fibrosis in a mouse model of systemic sclerosis.

Methods

Mice with bleomycin-induced lung fibrosis treated with progesterone subcutaneously for 21 and 28 days. Blood was collected for hormone and cytokine measurement at the end of treatment then, skin and lung tissues were harvested for histol

SUBMITTER: Vafashoar F 

PROVIDER: S-EPMC8667310 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature