A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells.

ABSTRACT:

Background

Mosaic loss of Y chromosome (LOY) is the most common somatic change that occurs in circulating white blood cells of older men. LOY in leukocytes is associated with increased risk for all-cause mortality and a range of common disease such as hematological and non-hematological cancer, Alzheimer's disease, and cardiovascular events. Recent genome-wide association studies identified up to 156 germline variants associated with risk of LOY. The objective of this study was to use these variants to calculate a novel polygenic risk score (PRS) for LOY, and to assess the predictive performance of this score in a large independent population of older men.

Results

We calculated a PRS for LOY in 5131 men aged 70 years and older. Levels of LOY were estimated using microarrays

SUBMITTER: Riaz M 

PROVIDER: S-EPMC8667399 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature