Polysaccharide CM1 from Cordyceps militaris hinders adipocyte differentiation and alleviates hyperlipidemia in LDLR^(+/-) hamsters.

ABSTRACT:

Background

Cordyceps militaris is cultured widely as an edible mushroom and accumulating evidence in mice have demonstrated that the polysaccharides of Cordyceps species have lipid-lowering effects. However, lipid metabolism in mice is significantly different from that in humans, making a full understanding of the mechanisms at play critical.

Methods

After 5 months, the hamsters were weighed and sampled under anesthesia after overnight fasting. The lipid-lowering effect and mechanisms of the polysaccharide CM1 was investigated by cellular and molecular technologies. Furthermore, the effect of the polysaccharide CM1 (100 μg/mL) on inhibiting adipocyte differentiation was investigated in vitro.

Results

CM1, a polysaccharide from C. militaris, significantly decreased pla

SUBMITTER: Yu WQ 

PROVIDER: S-EPMC8667404 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature