Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damage.

ABSTRACT:

Background

Autoptic pulmonary findings have been described in severe COVID-19 patients, but evidence regarding the correlation between clinical picture and lung histopathologic patterns is still weak.

Methods

This was a retrospective cohort observational study conducted at the referral center for infectious diseases in northern Italy. Full lung autoptic findings and clinical data of patients who died from COVID-19 were analyzed. Lung histopathologic patterns were scored according to the extent of tissue damage. To consider coexisting histopathologic patterns, hierarchical clustering of histopathologic findings was applied.

Results

Whole pulmonary examination was available in 75 out of 92 full autopsies. Forty-eight hospitalized patients (64%), 44 from ICU and four fro

SUBMITTER: Wu MA 

PROVIDER: S-EPMC8667540 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature